5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

Base Information

Chemical Name:5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid
CAS No.:1621255-10-4
Molecular Formula:C₃₄H₂₉F₈NO₄
Molecular Weight:667.596
Hs Code.:

5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

Synonyms:5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

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Chemical Property of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

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Technology Process of 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

There total 6 articles about 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1621255-01-3
methyl 5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylate

: 1621255-10-4
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 50 ℃; for 4h;

Reference yield:

: 1152029-16-7
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol

: 1621255-10-4
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium cyanoborohydride; acetic acid / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

4: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

5: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 50 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; sodium cyanoborohydride; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; 3: |Suzuki Coupling / 4: |Suzuki Coupling;

Reference yield:

: 1621256-02-7
(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-3-((3'-chloro-4'-fluoro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)-4-methyloxazolidin-2-one

: 1621255-10-4
5'-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-2,2'-difluorobiphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation

2: lithium hydroxide monohydrate; water / 1,4-dioxane / 4 h / 50 °C

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); lithium hydroxide monohydrate; water; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: |Suzuki Coupling;