4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Base Information

• Chemical Name: 4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile
• CAS No.: 1024603-85-7
• Molecular Formula: C₁₅H₁₀ClN₃OS
• Molecular Weight: 315.783
• Mol file: 1024603-85-7.mol

Synonyms:4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Chemical Property of 4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

There total 1 articles about 4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.8%

2,4-dichlorothieno[3,2-d]pyrimidine (16234-14-3) + 3,5-dimethyl-4-hydroxybenzonitrile (4198-90-7) → 4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile (1024603-85-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1021/acs.jmedchem.6b00738

Reference yield: 75.8%

4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile (1024603-85-7) → 4-((2-hydrazinylthieno[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 5h;

DOI:10.1111/cbdd.13373

Reference yield: 60.7%

4-((2-chlorothiophene[3,2-d]pyrimidin-4-yl)oxy)-3,5-dimethylbenzonitrile (1024603-85-7) + 5-amino-2-cyanopyridine (55338-73-3) → 5-((4-(4-Cyano-2,6-dimethylphenoxy)thieno[3,2-d]pyrimidin-2-yl)amino)picolinonitrile

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 12h; Inert atmosphere; Reflux;

upstream raw materials:

2,4-dichlorothieno[3,2-d]pyrimidine

3,5-dimethyl-4-hydroxybenzonitrile

Downstream raw materials:

4-(2-(4-cyanophenylamino)thieno[3,2-d]pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile