methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate

Base Information

• Chemical Name: methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate
• CAS No.: 144757-33-5
• Molecular Formula: C₄₁H₃₈N₄O₃
• Molecular Weight: 634.778
• Mol file: 144757-33-5.mol

Synonyms:methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate

Chemical Property of methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate

There total 2 articles about methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 3-oxoheptanoate (39815-78-6) + N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) → methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate (144757-33-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 10h;

DOI:10.1021/jm00024a008

Reference yield:

→ methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate (144757-33-5)

Guidance literature:

Reference yield: 70.0%

acetamidine hydrochloride (124-42-5) + methyl α-(1-oxopentyl)-2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-propanoate (144757-33-5) → 6-butyl-2-methyl-5-<<2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>pyrimidin-4(1H)-one (148564-13-0)

Guidance literature:

With sodium methylate; In 1,4-dioxane; methanol; for 20h; Ambient temperature;

DOI:10.1021/jm00024a008

upstream raw materials:

methyl 3-oxoheptanoate

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

Downstream raw materials:

6-butyl-2-methyl-5-<<2'-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4-yl>methyl>pyrimidin-4(1H)-one

milfasartan

methyl 2-<<4-butyl-2-methyl-6-oxo-5-<<2'-(1H-tetrazol-5-yl)<1,1'-biphenyl>-4-yl>methyl>-1(6H)-pyrimidinyl>methyl>-3-furancarboxylate

3-Benzyl-6-butyl-2-methyl-5-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-pyrimidin-4-one