(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester

Base Information

• Chemical Name: (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester
• CAS No.: 1053711-72-0
• Molecular Formula: C₂₂H₂₉ClN₂O₄
• Molecular Weight: 420.936
• Mol file: 1053711-72-0.mol

Synonyms:(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester

Chemical Property of (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester

There total 1 articles about (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-1H-Indole-2-carboxylic acid (10517-21-2) + 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester (119642-26-1) → (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester (1053711-72-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 23 ℃; for 18h;

DOI:10.1021/jm980264k

Reference yield:

(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester (1053711-72-0) → (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid

Guidance literature:

With sodium hydroxide; In methanol; at 25 ℃; for 2h;

DOI:10.1021/jm980264k

Reference yield:

(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester (1053711-72-0) → 5-Chloro-1H-indole-2-carboxylic acid ((1S,2R)-1-cyclohexylmethyl-2-dimethylcarbamoyl-2-hydroxy-ethyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 2 h / 25 °C

2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / dimethylformamide / 18 h / 23 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm980264k

upstream raw materials:

5-chloro-1H-Indole-2-carboxylic acid

2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester