119642-26-1

Basic information

• Product Name: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester
• Synonyms: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester
• CAS NO: 119642-26-1
• Molecular Weight: 243.346
• Mol File: 119642-26-1.mol

Chemical Properties

• CAS DataBase Reference: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester(119642-26-1)
• EPA Substance Registry System: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester(119642-26-1)

Safety Data

• Hazardous Substances Data: 119642-26-1(Hazardous Substances Data)

Upstream product

• 5664-21-1 cyclohexylacetaldehyde 
• 129397-35-9 [Bis-(4-methoxy-phenyl)-methyl]-[2-cyclohexyl-eth-(E)-ylidene]-amine 
• 129397-40-6 (3R*,4S*)-3-benzyloxy-4-cyclohexylmethyl-1-(di-p-anisylmethyl)-2-azetidinone 
• 129397-38-2 (3R*,4S*)-1-benzyl-3-benzyloxy-4-cyclohexylmethyl-2-azetidinone 
• 5452-75-5 ethyl 2-cyclohexylacetate 
• 129397-42-8 isopropyl (2R*,3S*)-2-benzyloxy-4-cyclohexyl-3-(di-p-anisylmethyl)aminobutyrate 
• 129397-41-7 isopropyl (2R*,3S*)-3-benzylamino-2-benzyloxy-4-cyclohexylbutyrate 
• 130115-21-8 3-Benzyloxy-1-[bis-(4-methoxy-phenyl)-methyl]-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one 
• 130115-22-9 1-Benzyl-3-benzyloxy-4-((R)-tert-butoxy-phenyl-methyl)-azetidin-2-one 
• 130115-10-5 (2R,3S,4R)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester 
• 130115-11-6 (2R,3S,4R)-3-Benzylamino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester 
• 130115-10-5 isopropyl (2R,3S,4R)-3-amino-2-benzyloxy-4-hydroxybutyrate 
• 130115-11-6 isopropyl (2R,3S,4R)-3-benzylamino-2-benzyloxy-4-hydroxybutyrate 
• 130193-84-9 (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone 

Downstream Products

• 141280-91-3 (2S,3R)-2-Acetoxy-3-acetylamino-4-cyclohexyl-butyric acid isopropyl ester 
• 1053711-72-0 (2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester 
• 141280-91-3 isopropyl (2R,3S)-3-acetamido-2-acetoxy-4-cyclohexylbutyrate 
• 121506-22-7 (2R,3S)-nor-C-statine hydrochloride 

Relevant articles and documents

A Stereoselective Synthesis of the (2R,3S)- and (2S,3R)-3-Amino-2-hydroxybutyric Acid Derivatives, the Key Components of a Renin Inhibitor and Bestatin

The title synthesis was achieved by featuring the -cycloaddition reaction of benzyloxyketene with a chiral imine derived from methyl (R)- or (S)-mandelate, alcoholysis of the formed 3,4-cis disubstituted β-lactam under acidic conditions, and reductiv

A Novel Synthesis of nor-C-Statine.

A new synthesis of nor-C-statine is described.Benzylation of malate dianion, differentiation of the two carboxylates and a Hofmann degradation of one of the carboxylates constitute the key steps of the synthesis.

A novel synthesis of the (2R,3S)-and (2S,3R)-3-amino-2-hydroxycarboxylic acid derivatives, the key components of a renin inhibitor and bestatin, from methyl (R)- and (S)-mandelate

The title synthesis could be accomplished by featuring the [2+2]-cycloaddition reaction of a chiral imine with benzyloxyketene, alcoholysis of the formed 2-azetidinone derivative, and reductive removal of the mandelate-derived benzylic oxygen by way of a 2-oxazolidone derivative.