N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

Base Information

Chemical Name:N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide
CAS No.:1123580-38-0
Molecular Formula:C₂₅H₂₀N₄O₂S
Molecular Weight:440.525
Hs Code.:

Synonyms:N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

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Chemical Property of N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

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Technology Process of N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

There total 1 articles about N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1123580-36-8
N-[5-(4-aminophenoxy)-2-methylphenyl]-3-(1-cyanocyclopropyl)benzamide

: 333-20-0
potassium thioacyanate

: 1123580-38-0
N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

Guidance literature:: potassium thioacyanate; With acetic acid; at 20 ℃; for 0.166667h;

N-[5-(4-aminophenoxy)-2-methylphenyl]-3-(1-cyanocyclopropyl)benzamide; With acetic acid; at 20 ℃; for 0.5h;

Reference yield: 75.0%

: 1123580-38-0
N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

: 62348-20-3
oxazol-4-ylcarbonyl chloride

: 1123580-40-4
N-[6-(3-{[3-(1-cyanocyclopropyl)benzoyl]amino}-4-methylphenoxy)-1,3-benzothiazol-2-yl]-1,3-oxazole-4-carboxamide

Guidance literature:: N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide; oxazol-4-ylcarbonyl chloride; In ISOPROPYLAMIDE; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In water;

Reference yield: 65.0%

: 1123580-38-0
N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide

: 13831-31-7
Acetoxyacetyl chloride

: 1123580-47-1
3-(1-cyanocyclopropyl)-N-(5-{[2-(glycoloylamino)-1,3-benzothiazol-6-yl]oxy}-2-methylphenyl)benzamide

Guidance literature:: N-{5-[(2-amino-1,3-benzothiazol-6-yl)oxy]-2-methylphenyl}-3-(1-cyanocyclopropyl)benzamide; Acetoxyacetyl chloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;