5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Base Information

Chemical Name:5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine
CAS No.:216449-54-6
Molecular Formula:C₃₅H₅₃N₃O₅Si₂
Molecular Weight:651.994
Hs Code.:

Synonyms:5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Suppliers and Price of 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

There total 7 articles about 5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 573671-47-3
5-(3-benzyloxy-benzyl)-1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 216449-54-6
5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Guidance literature:: 5-(3-benzyloxy-benzyl)-1-[3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-methyl-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione; With pyridine; dmap; trichlorophosphate; In acetonitrile;

With ammonia; at 0 - 20 ℃; for 2h;
DOI:10.1016/S0960-894X(02)01082-X

Reference yield:

: 37076-71-4
5-deoxy-1,2,3-tri-O-acetyl-D-ribofuranose

: 216449-54-6
5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: HMDS; (NH₄)2SO₄ / 5 h / Heating

1.2: 89 percent / SnCl₄ / acetonitrile; nitromethane / 3 h / 0 °C

2.1: aq. NaOH / methanol / 0.5 h / 0 °C

3.1: imidazole / dimethylformamide / 23 h / 20 °C

4.1: POCl₃; DMAP; pyridine / acetonitrile

4.2: 75 percent / liq. NH₃ / 2 h / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; ammonium sulfate; sodium hydroxide; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(02)01082-X

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 216449-54-6
5-(3-benzyloxybenzyl)-2',3'-bis-O-(tert-butyldimethylsilyl)-5'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 23 h / 20 °C

2.1: POCl₃; DMAP; pyridine / acetonitrile

2.2: 75 percent / liq. NH₃ / 2 h / 0 - 20 °C

With pyridine; 1H-imidazole; dmap; trichlorophosphate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(02)01082-X