5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Base Information

Chemical Name:5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine
CAS No.:1345412-75-0
Molecular Formula:C₄₉H₅₈N₂O₁₁
Molecular Weight:851.006
Hs Code.:

Synonyms:5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

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Chemical Property of 5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

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Technology Process of 5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

There total 3 articles about 5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1345412-69-2
1-O-(1-adamantyl)-4-O-propargyl triethylene glycol

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 1345412-75-0
5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 0.333333h; Microwave irradiation; Inert atmosphere;
DOI:10.1039/c1ob05929g

Reference yield:

: 208827-90-1
O-propargyl triethylene glycol

: 1345412-75-0
5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 5 h / 180 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.33 h / 50 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1039/c1ob05929g

Reference yield:

: 768-90-1
1-Adamantyl bromide

: 1345412-75-0
5-[12-(adamantyl-1-oxyl)-(4,7,10-trioxadodec-1-ynyl)]-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 5 h / 180 °C / Inert atmosphere

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / N,N-dimethyl-formamide / 0.33 h / 50 °C / Microwave irradiation; Inert atmosphere

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In N,N-dimethyl-formamide; 2: Sonogashira coupling;
DOI:10.1039/c1ob05929g