4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE

Base Information

• Chemical Name: 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE
• CAS No.: 423116-18-1
• Molecular Formula: C15H15 N O3
• Molecular Weight: 257.289
• Hs Code.: 2925190090
• Mol file: 423116-18-1.mol

Synonyms:4-[Phthalimidomethyl]cyclohexanone

Chemical Property of 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6
• Boiling Point: 421.4°Cat760mmHg
• Flash Point: 193.2°C
• PSA: 54.45000
• Density: 1.291g/cm³
• LogP: 1.97980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-N-Phthaloylglyaminomethylcyclohexanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE

There total 4 articles about 4-N-PHTHALOYLGLYAMINOMETHYL-CYCLOHEXANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

phthalic anhydride (85-44-9) + (1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine (30482-25-8) → 2-[(4-oxocyclohexyl)methyl]isoindoline-1,3-dione (423116-18-1)

Guidance literature:

at 135 ℃; for 2h;

DOI:10.1021/jo016250v

Reference yield:

2-(1,4-dioxaspiro[4.5]decan-8-ylmethyl)isoindoline-1,3-dione → 2-[(4-oxocyclohexyl)methyl]isoindoline-1,3-dione (423116-18-1)

Guidance literature:

With formic acid; In water; at 20 ℃; for 16h;

Reference yield:

1,4-dioxaspiro<4.5>decane-8-carbonitrile (69947-09-7) → 2-[(4-oxocyclohexyl)methyl]isoindoline-1,3-dione (423116-18-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / LiAlH₄ / tetrahydrofuran

2: 89 percent / 2 h / 135 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo016250v

upstream raw materials:

phthalic anhydride

(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine

1,4-dioxaspiro<4.5>decane-8-carbonitrile

cyclohexanedione monoethylene ketal

Downstream raw materials:

2-((4-hydroxycyclohexyl)methyl)isoindoline-1,3-dione

2-{[4-(hydroxyimino)cyclohexyl]methyl}isoindoline-1,3-dione

2-{[4-(prop-2-enyloxyimino)cyclohexyl]methyl}isoindoline-1,3-dione

Refernces

• 1、 -. "PYRIDINYL PYRAZOLES AS MODULATORS OF RORyT". . . Retrieved 2020/01/08.
• 2、 -. "PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORgT". . . Retrieved 2020/01/09.