30482-25-8

Basic information

• Product Name: 8-AMinoMethyl-1,4-dioxaspiro[4.5]decane
• Synonyms: 8-AMinoMethyl-1,4-dioxaspiro[4.5]decane;1,4-Dioxaspiro[4.5]decane-8-MethanaMine;1,4-Dioxaspiro[4.5]decan-8-ylMethanaMine;(1,4-dioxa-spiro[4.5]dec-8-yl)-Methyl-aMine
• CAS NO: 30482-25-8
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.23678
• Mol File: 30482-25-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 270.059 °C at 760 mmHg
• Flash Point: 126.861 °C
• Appearance: /
• Density: 1.088 g/cm³
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: 1.505
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 10.20±0.29(Predicted)
• CAS DataBase Reference: 8-AMinoMethyl-1,4-dioxaspiro[4.5]decane(CAS DataBase Reference)
• NIST Chemistry Reference: 8-AMinoMethyl-1,4-dioxaspiro[4.5]decane(30482-25-8)
• EPA Substance Registry System: 8-AMinoMethyl-1,4-dioxaspiro[4.5]decane(30482-25-8)

Safety Data

• Hazardous Substances Data: 30482-25-8(Hazardous Substances Data)

Usage

Uses

8-Aminomethyl-1,4-dioxaspiro[4.5]decane is used to prepare brain-penetrating cathepsin S inhibitors.

InChI:InChI=1/C9H17NO2/c10-7-8-1-3-9(4-2-8)11-5-6-12-9/h8H,1-7,10H2

Upstream product

• 30482-24-7 1,4-dioxaspiro<4,5>decane-8-carboxamide 
• 26845-47-6 methyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 147767-55-3 (1,4-dioxaspiro[4.5]dec-8-yl)methyl methanesulfonic acid 
• 17159-79-4 ethyl 4-oxocyclohexane-1-carboxylate 
• 1489-97-0 ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate 
• 23521-81-5 (1,4-dioxaspiro[4.5]dec-8-yl)methanol 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 

Downstream Products

• 42949-24-6 1-azaadamantane-4-one 
• 423116-18-1 2-[(4-oxocyclohexyl)methyl]isoindoline-1,3-dione 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 
• 867023-69-6 4,5,6,7-tetrahydro-2H-indazol-5-ylmethanamine 
• 869895-16-9 benzyl 1,4-dioxaspiro[4.5]dec-8-ylmethylcarbamate 
• 478841-18-8 2-((4-hydroxycyclohexyl)methyl)isoindoline-1,3-dione 
• 869895-17-0 benzyl (4-oxocyclohexyl)methylcarbamate 

Relevant articles and documents

A short synthesis of 1-azaadamantan-4-one and the 4r and 4s isomers of 4-amino-1-azaadamantane

Reductive homologation of 1,4-cyclohexanedione monoethylene acetal (1) with tosylmethylisocyanide and subsequent reduction with lithium aluminum hydride gave 1,4-dioxaspiro[4.5]decan-8-yl-methylamine (3) which was converted to 1-azatricyclo[3.3.1.13,7] decan-4-one (4) via a known double-Mannich condensation. Reductive amination of this ketone gave the corresponding 1-azatricyclo[3.3.1.13,7]decan-4 (s and r)-amines (9 and 10) which were separated on a multigram scale as their corresponding tosylamides 7 and 8, followed by deprotection.

PYRIDINYL PYRAZOLES AS MODULATORS OF RORyT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.

PHENYL SUBSTITUTED PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, R3, R4, R5, R6, R7, R8, and Q are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.