(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

Base Information

Chemical Name:(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde
CAS No.:1623755-76-9
Molecular Formula:C₃₆H₄₈O₄Si
Molecular Weight:572.86
Hs Code.:

Synonyms:(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

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Chemical Property of (1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

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Technology Process of (1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

There total 8 articles about (1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1623755-25-8
((1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutyl)methanol

: 1623755-76-9
(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1002/anie.201400617

Reference yield:

: 13259-28-4
bicyiclo<3.2.0>hept-2-en-6-ol

: 1623755-76-9
(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

2.1: potassium dihydrogenphosphate / tert-butyl methyl ether; pentane / 20 °C / pH 7 / Resolution of racemate; Enzymatic reaction

3.1: lithium hydroxide monohydrate / methanol; water / 0.5 h / 20 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

5.1: ozone / dichloromethane; methanol / -78 °C

5.2: dehumidified air / 3 h / -78 - 20 °C

6.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

7.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux

With pyridine; 1H-imidazole; dmap; potassium dihydrogenphosphate; lithium hydroxide monohydrate; ozone; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; tert-butyl methyl ether; water; ethyl acetate; N,N-dimethyl-formamide; pentane;
DOI:10.1002/anie.201400617

Reference yield:

: 1623755-21-4
((1S,5R,6S)-bicyclo[3.2.0]hept-2-en-6-yloxy)triisopropylsilane

: 1623755-76-9
(1R,2R,3S)-2-(2-((4-methoxyphenyl)diphenylmethoxy)ethyl)-3-((triisopropylsilyl)oxy)cyclobutanecarbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: ozone / dichloromethane; methanol / -78 °C

1.2: dehumidified air / 3 h / -78 - 20 °C

2.1: dmap; pyridine / dichloromethane / 2 h / -42 °C / Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / Inert atmosphere; Reflux

With pyridine; dmap; ozone; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; dichloromethane; ethyl acetate;
DOI:10.1002/anie.201400617