[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

Base Information

Chemical Name:[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide
CAS No.:354573-95-8
Molecular Formula:C₁₆H₂₄N₂O₄
Molecular Weight:308.378
Hs Code.:

Synonyms:[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

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Chemical Property of [3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

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Technology Process of [3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

There total 4 articles about [3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 506-59-2
N,N-dimethylammonium chloride

: 354574-30-4
[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid

: 354573-95-8
[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/jm020329q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 354573-95-8
[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / tetrahydrofuran / 24 h / Heating

2.1: n-BuLi / tetrahydrofuran / -40 - -10 °C

2.2: 80 percent / tetrahydrofuran

3.1: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; diisopropylethylamine / dimethylformamide / 48 h / 20 °C

With n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020329q

Reference yield:

: 545424-34-8
3-methoxy-2-(tert-butyloxycarbonylamino)toluene

: 354573-95-8
[3-methoxy-2-(tert-butyloxycarbonylamino)]phenylacetic acid dimethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -40 - -10 °C

1.2: 80 percent / tetrahydrofuran

2.1: 78 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotriazole; diisopropylethylamine / dimethylformamide / 48 h / 20 °C

With n-butyllithium; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020329q