tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

Base Information

Chemical Name:tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate
CAS No.:1610614-75-9
Molecular Formula:C₂₂H₁₉BrCl₂F₃NO₂S₂
Molecular Weight:601.336
Hs Code.:

Synonyms:tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

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Chemical Property of tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

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Technology Process of tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

There total 4 articles about tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1610614-73-7
2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzenethiol

: 1610614-75-9
tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

Guidance literature:: 2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]benzenethiol; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; for 0.666667h;

Reference yield:

: 1610614-78-2
1-(3-bromo-4-tert-butylsulfanylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-sulfanyl-butan-1-one

: 1610614-75-9
tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium bisulphate; potassium hydroxide / tetrahydrofuran; water / 0.5 h / 20 °C

2.1: aluminum (III) chloride / toluene / 5.17 h / 0 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0 °C

3.2: 0.67 h

With aluminum (III) chloride; ammonium bisulphate; potassium tert-butylate; potassium hydroxide; In tetrahydrofuran; water; toluene;

Reference yield:

: 1610609-40-9
(Z)-1-(3-bromo-4-tert-butylsulfanyl-phenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-but-2-en-1-one

: 1610614-75-9
tert-butyl 2-[2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]phenyl]sulfanylacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tiolacetic acid; triethylamine / 24 h / 20 °C / Inert atmosphere

2.1: ammonium bisulphate; potassium hydroxide / tetrahydrofuran; water / 0.5 h / 20 °C

3.1: aluminum (III) chloride / toluene / 5.17 h / 0 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0 °C

4.2: 0.67 h

With aluminum (III) chloride; ammonium bisulphate; potassium tert-butylate; triethylamine; tiolacetic acid; potassium hydroxide; In tetrahydrofuran; water; toluene;