5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI)

Base Information

• Chemical Name: 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI)
• CAS No.: 418803-02-8
• Molecular Formula: C₁₅H₁₈N₂O₃
• Molecular Weight: 274.32
• Mol file: 418803-02-8.mol

Synonyms:5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI)

Chemical Property of 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI)

Chemical Property:

• PSA: 67.43000
• LogP: 2.84360

Purity/Quality:

ETHYL-6-METHYL-4-(2-METHYLPHENYL)-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI)

There total 5 articles about 5-Pyrimidinecarboxylicacid,1,2,3,4-tetrahydro-6-methyl-4-(2-methylphenyl)-2-oxo-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl acetoacetate (141-97-9) + 2-methylphenyl aldehyde (529-20-4) + urea (57-13-6) → ethyl 6-methyl-4-(2-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (418803-02-8)

Guidance literature:

With [1-(3-sulfonic acid)]propyl-3-methylimidazolium hydrogen sulfate; In ethanol; at 80 ℃; for 3h; Time;

DOI:10.1002/jhet.3292

Reference yield: 84.0%

2-diacetoxymethyltoluene (31675-37-3) + ethyl acetoacetate (141-97-9) + urea (57-13-6) → ethyl 6-methyl-4-(2-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (418803-02-8)

Guidance literature:

With iron(III) chloride hexahydrate; for 0.25h; Microwave irradiation; neat (no solvent);

DOI:10.1080/10426500902796931

Reference yield: 16.0%

ethyl acetoacetate (141-97-9) + 2-methylphenyl aldehyde (529-20-4) + urea (57-13-6) → diethyl 2,6-dimethyl-4-(o-tolyl)-1,4-dihydropyridine-3,5-dicarboxylate (53219-32-2) + ethyl 6-methyl-4-(2-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (418803-02-8)

Guidance literature:

With sulfated zirconia; at 100 ℃; for 4h;

DOI:10.3390/11100731

upstream raw materials:

ethyl acetoacetate

2-methylphenyl aldehyde

urea

2-diacetoxymethyltoluene

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