5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Base Information

• Chemical Name: 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile
• CAS No.: 1469772-13-1
• Molecular Formula: C₂₃H₁₃ClF₂N₆O
• Molecular Weight: 462.846
• Mol file: 1469772-13-1.mol

Synonyms:5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Chemical Property of 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile

There total 4 articles about 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-2,4,6-trifluoroisophthalonitrile (1897-50-3) + 8-amino-5-(m-tolylamino)quinazolin-4(3H)-one (1469771-90-1) → 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile (1469772-13-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 75 ℃; for 1h;

DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

5-chloro-8-nitro-quinazolin-4(3H)-one (400784-50-1) → 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile (1469772-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

3: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.08.068

Reference yield:

1-amino-3-methylbenzene (108-44-1) → 5-chloro-2,4-difluoro-6-(4-oxo-5-(m-tolylamino)-3,4-dihydroquinazolin-8-ylamino)isophthalonitrile (1469772-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; N,N-dimethyl-formamide / 12 h / 80 °C

2: hydrogen; palladium 10% on activated carbon / tetrahydrofuran

3: potassium carbonate / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 75 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.08.068

upstream raw materials:

5-chloro-2,4,6-trifluoroisophthalonitrile

8-amino-5-(m-tolylamino)quinazolin-4(3H)-one

5-chloro-8-nitro-quinazolin-4(3H)-one

1-amino-3-methylbenzene