ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

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Chemical Name:ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate
CAS No.:1313053-07-4
Molecular Formula:C₂₆H₃₀N₂O₄
Molecular Weight:434.535
Hs Code.:

Synonyms:ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

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Chemical Property of ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

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Technology Process of ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

There total 8 articles about ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1313053-12-1
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-benzyloxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

: 1313053-07-4
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-benzyloxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate; With boron tribromide; In dichloromethane; at -78 ℃; for 2h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane; Inert atmosphere;

Reference yield:

: 102127-34-4
4-bromo-3-methoxyphenol

: 1313053-07-4
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanesulfonic acid / dichloromethane / 29 h / 54 °C

2.1: potassium carbonate / acetone / 17.25 h / Reflux; Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 26 h / 90 °C

5.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

5.2: Inert atmosphere

With n-butyllithium; methanesulfonic acid; boron tribromide; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane; water; acetone;

Reference yield:

: 140-88-5,9003-32-1
ethyl acrylate

: 1313053-07-4
ethyl (E)-3-[2-(5'-(1-adamantyl)-4'-hydroxy-2'-methoxyphenyl)-5-pyrimidinyl]-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / palladium diacetate; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 3.5 h / 115 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 26 h / 90 °C

3.1: boron tribromide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: Inert atmosphere

With boron tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; tris-(o-tolyl)phosphine; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;