102127-34-4

Basic information

• Product Name: 4-Bromo-3-methoxyphenol
• Synonyms: 4-BROMO-3-METHOXYPHENOL;3-methoxy-4-bromophenol;4-Bromo-5-methoxyphenol;2-Bromo-5-hydroxyanisole;4-Bromo-3-methoxyphenol, >=97%;Phenol, 4-bromo-3-methoxy-
• CAS NO: 102127-34-4
• Molecular Formula: C₇H₇BrO₂
• Molecular Weight: 203.03
• EINECS: 1806241-263-5
• Mol File: 102127-34-4.mol
• Article Data: 18

Chemical Properties

• Melting Point: 75-78°C
• Boiling Point: 279.3 °C at 760 mmHg
• Flash Point: 122.7 °C
• Appearance: /
• Density: 1.585 g/cm³
• Vapor Pressure: 0.00239mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.02±0.18(Predicted)
• CAS DataBase Reference: 4-Bromo-3-methoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-methoxyphenol(102127-34-4)
• EPA Substance Registry System: 4-Bromo-3-methoxyphenol(102127-34-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-37
• WGK Germany: 3
• Hazardous Substances Data: 102127-34-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H7BrO2/c1-10-7-4-5(9)2-3-6(7)8/h2-4,9H,1H3

Upstream product

• 150-19-6 O-methylresorcine 
• 33285-71-1 1-methoxy-3-trimethylsilyloxybenzene 
• 6626-15-9 4-Bromoresorcinol 
• 98-59-9 p-toluenesulfonyl chloride 
• 74-88-4 methyl iodide 
• 7355-22-8 5-bromo-4-hydroxysalicylic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 494773-45-4 4-bromo-3-hydroxy-phenyl 4-methyl-benzenesulfonate 
• 98437-41-3 5-bromo-2-hydroxy-4-methoxybenzoic acid 
• 7732-18-5 water 
• 137396-01-1 4-bromo-3-methoxyphenyl 4-methylbenzenesulfonate 

Downstream Products

• 171768-67-5 4-benzyloxy-1-bromo-2-methoxybenzene 
• 1279014-70-8 (S)-2-(2-methoxy-2',3'-dimethylbiphenyl-4-yloxymethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one 
• 1259517-73-1 ethyl 5-{[4-bromo-3-(methyloxy)phenyl]oxy}pentanoate 
• 885053-19-0 4-bromo-3-methoxyphenyl acetate 
• 57543-36-9 5-bromo-2-hydroxy-4-methoxybenzaldehyde 
• 1128105-60-1 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenol 
• 137396-08-8 2-[2-(4-Acetoxy-2-methoxy-phenyl)-2-oxo-eth-(Z)-ylidene]-pentanoic acid methyl ester 
• 176391-62-1 4,5-dihydro-2-<2'-methoxy-4',6-bis(1-methylethoxy)<1,1'-biphenyl>-2-yl>-4,4-dimethyloxazole 
• 199858-21-4 N,N-diethyl O-[4-methoxy-5-isopropoxy-2-(2-methoxy-5-methoxymethoxyphenyl)]-1-naphthylcarbamate 
• 199858-11-2 N,N-diethyl O-[5-isopropoxy-4-methoxy-2-(4-isopropoxy-2-methoxyphenyl)]-1-naphthylcarbamate 
• 199858-19-0 2-methoxy-4-methoxymethoxyphenylboronic acid 
• 199858-09-8 4-isopropoxy-2-methoxyphenylboronic acid 
• 80155-95-9 defucogilvocarcin V 
• 936030-66-9 9-[1-(2-methoxy-4-methoxycarbonylmethoxyphenyl)]-3H-xanthen-3-on-6-yl-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranoside) 

Relevant articles and documents

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Copper(II) bromide: A simple and selective monobromination reagent for electron-rich aromatic compounds

Copper(II) bromide was found to be a simple and efficient reagent for monobromination of electron-rich aromatic compounds at room temperature. The reaction proceeded smoothly with phenols, aryl alkyl ethers, and aromatic amines to afford the corresponding monobrominated product selectively in moderate to good yields. Copyright Taylor & Francis Group, LLC.

Synthesis method of 2-bromo-5-methoxyphenol

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Visible-light photoredox catalysis enabled bromination of phenols and alkenes

A mild and efficient methodology for the bromination of phenols and alkenes has been developed utilizing visible light-induced photoredox catalysis. The bromine was generated in situ from the oxidation of Br- by Ru(bpy)33+, both of which resulted from the oxidative quenching process.