1-PHENYL-2-PYRAZIN-2-YLETHANONE

Base Information

• Chemical Name: 1-PHENYL-2-PYRAZIN-2-YLETHANONE
• CAS No.: 40061-45-8
• Molecular Formula: C12H10 N2 O
• Molecular Weight: 198.224
• Hs Code.: 2933990090
• Mol file: 40061-45-8.mol

Synonyms:Acetophenone,2-(pyrazinyl)- (6CI,7CI); Ethanone, 1-phenyl-2-pyrazinyl- (9CI);2-Phenacylpyrazine; Phenyl 2-pyrazylmethyl ketone

Chemical Property of 1-PHENYL-2-PYRAZIN-2-YLETHANONE

Chemical Property:

• Boiling Point: 343.4±27.0 °C(Predicted)
• PKA: 0.51±0.10(Predicted)
• PSA: 42.85000
• Density: 1.179±0.06 g/cm3(Predicted)
• LogP: 1.90200

Purity/Quality:

98%Min ^*data from raw suppliers

1-Phenyl-2-pyrazin-2-ylethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYL-2-PYRAZIN-2-YLETHANONE

There total 7 articles about 1-PHENYL-2-PYRAZIN-2-YLETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-chloropyrazin (14508-49-7) + potassium enolate of acetophenone (15480-89-4) → 1-phenyl-2-(pyrazin-2-yl)ethanone (40061-45-8)

Guidance literature:

In diethyl ether; ammonia; for 0.25h; Mechanism; Product distribution; effect of inhibitor (di-tert-butyl-nitroxide);

DOI:10.1021/jo00315a013

Reference yield: 68.0%

2-Methylpyrazine (109-08-0) + benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → 1-phenyl-2-(pyrazin-2-yl)ethanone (40061-45-8)

Guidance literature:

Reference yield: 50.1%

2-iodopyrazine (32111-21-0) + acetophenone (98-86-2) → 1-phenyl-2-(pyrazin-2-yl)ethanone (40061-45-8)

Guidance literature:

acetophenone; With (2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-N-methylamino-1,1′-biphenyl)]palladium(II) methanesulfonate; sodium t-butanolate; In toluene; at 20 ℃; for 0.166667h; Microwave irradiation;

2-iodopyrazine; In toluene; at 130 ℃; for 0.166667h; Sealed tube; Microwave irradiation;

DOI:10.1021/acs.joc.9b00446

upstream raw materials:

2-Methylpyrazine

2-chloropyrazin

potassium enolate of acetophenone

(Z)-1-Phenyl-2-pyrazin-2-yl-ethenol

Downstream raw materials:

(Z)-1-Phenyl-2-pyrazin-2-yl-ethenol

4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-6-phenyl-5-(pyrazin-2-yl)-3,4-dihydropyrimidin-2(1H)-one

C₁₈H₁₈N₂O₄

C₁₆H₁₄N₂O

Refernces

• 1、 Quillen, Andrew,Nguyen, Quynh,Neiser, Matthew,Lindsay, Kara,Rosen, Alexander,Ramirez, Stephen,Costan, Stefana,Johnson, Nathan,Do, Thuy Donna,Rodriguez, Oscar,Rivera, Diego,Atesin, Abdurrahman,Ate?in, Tülay Aygan,Ma, Lili. "Palladium-Catalyzed Direct α-C(sp3) Heteroarylation of Ketones under Microwave Irradiation". . p. 7652 - 7663. Retrieved 2019/05/22.
• 2、 -. "Process of preparing benzodiazepine compounds useful as antagonists of CCK or of gastrine". . . Retrieved 2008/06/13.