L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

Base Information

Chemical Name:L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester
CAS No.:110774-04-4
Molecular Formula:C₂₈H₂₉NO₆
Molecular Weight:475.541
Hs Code.:

Synonyms:L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

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Chemical Property of L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

Chemical Property:

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Technology Process of L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

There total 5 articles about L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 105205-69-4
L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)alanine methyl ester

: 74-88-4
methyl iodide

: 110774-04-4
L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 20h; Heating;
DOI:10.1021/jo00232a044

Reference yield:

: 32404-28-7
(S)-3-(3-acetyl-4-hydroxyphenyl)-2-aminopropanoic acid hydrochloride

: 110774-04-4
L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / HCl (g) / 1 h / 25 °C

2: 90 percent / Na₂CO₃ / H₂O; diethyl ether / 3 h / 25 °C

3: 93 percent / K₂CO₃, tetra-n-butylammonium iodide / dimethylformamide / 6 h / 23 °C

4: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 20 h / Heating

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00232a044

Reference yield:

: 60-18-4,18875-48-4,25619-78-7,30704-25-7
L-tyrosine

: 110774-04-4
L-3-(3-acetyl-4-(benzyloxy)phenyl)-N-(benzyloxycarbonyl)-N-methylalanine methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / AlCl₃ / nitrobenzene / 6 h / 100 °C

2: 74 percent / HCl (g) / 1 h / 25 °C

3: 90 percent / Na₂CO₃ / H₂O; diethyl ether / 3 h / 25 °C

4: 93 percent / K₂CO₃, tetra-n-butylammonium iodide / dimethylformamide / 6 h / 23 °C

5: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 20 h / Heating

With hydrogenchloride; aluminium trichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium carbonate; potassium carbonate; In tetrahydrofuran; diethyl ether; water; nitrobenzene; N,N-dimethyl-formamide;
DOI:10.1021/jo00232a044