N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide
• CAS No.: 1316672-53-3
• Molecular Formula: C₂₇H₄₄N₆O₆
• Molecular Weight: 548.683

Synonyms:N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide

Chemical Property of N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide

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Technology Process of N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide

There total 1 articles about N-(tert-butoxycarbonyl)-L-isoleucyl-N₁-[(1S)-2-azido-1-methylethyl]-N₂-(2,4-dimethoxybenzyl)-2-methylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

N-(tert-butyloxycarbonyl)-L-isoleucine (13139-16-7) + (S)-1-azido-2-isocyanopropane (1223635-84-4) + 2,4-Dimethoxybenzylamine (20781-20-8) + acetone (67-64-1) → N-(tert-butoxycarbonyl)-L-isoleucyl-N1-[(1S)-2-azido-1-methylethyl]-N2-(2,4-dimethoxybenzyl)-2-methylalaninamide (1316672-53-3)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1039/c0ob01188f

Reference yield: 88.0%

N-(tert-butoxycarbonyl)-L-isoleucyl-N1-[(1S)-2-azido-1-methylethyl]-N2-(2,4-dimethoxybenzyl)-2-methylalaninamide (1316672-53-3) + 3-ethynyl-3β-hydroxy-20(29)-lupen-28-oic acid (1262836-52-1) → N-[(1,1-dimethylethoxy)carbonyl]-L-isoleucyl-N1-[(1S)-2-[4-[3,28-dihydroxy-28-oxolup-20(29)-en-3-yl]-1H-1,2,3-triazol-1-yl]-1-methylethyl]-N2-[(2,4-dimethoxyphenyl)methyl]-2-methyl-alaninamide

Guidance literature:

With copper(l) chloride; In toluene; at 110 ℃; for 24h;

DOI:10.1039/c4md00236a

Reference yield: 77.0%

N-(tert-butoxycarbonyl)-L-isoleucyl-N1-[(1S)-2-azido-1-methylethyl]-N2-(2,4-dimethoxybenzyl)-2-methylalaninamide (1316672-53-3) + methyl (3α,5β,12α)-3,12-bis{[4-(prop-2-yn-1-yloxy)benzoyl]oxy}cholan-24-oate (1316672-60-2) → C99H142N12O20

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; at 40 ℃; for 10h;

DOI:10.1039/c0ob01188f

upstream raw materials:

N-(tert-butyloxycarbonyl)-L-isoleucine

(S)-1-azido-2-isocyanopropane

2,4-Dimethoxybenzylamine

acetone

Downstream raw materials:

C₈₆H₁₃₄N₁₂O₁₇

N-(tert-butoxycarbonyl)-L-isoleucyl-N²-(2,4-dimethoxybenzyl)-N₁-{(1S)-2-[4-({[3-(8-fluoro-2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)propanoyl]oxy}methyl)-1H-1,2,3-triazol-1-yl]-1-methylethyl}-2-methylalaninamide

N-(tert-butoxycarbonyl)-L-isoleucyl-N²-(2,4-dimethoxybenzyl)-N₁-{(1S)-2-[4-({[3-(2,8-dimethyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)propanoyl]oxy}methyl)-1H-1,2,3-triazol-1-yl]-1-methylethyl}-2-methylalaninamide

N-(tert-Butoxycarbonyl)-L-isoleucyl-N²-(2,4-dimethoxybenzyl)-N₁-{(1S)-2-[4-({[3-(8-methoxy-2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)propanoyl]oxy}methyl)-1H-1,2,3-triazol-1-yl]-1-methylethyl}-2-methylalaninamide

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