1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester
• CAS No.: 78061-46-8
• Molecular Formula: C₂₂H₁₈N₂O₃
• Molecular Weight: 358.397

Synonyms:1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester

Chemical Property of 1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester

There total 1 articles about 1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

indole (120-72-9) + 4-pyridinecarboxylic acid, methyl ester (2459-09-8) + benzoyl chloride (98-88-4) → 1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester (78061-46-8)

Guidance literature:

In dichloromethane; at 0 ℃; for 2h;

Reference yield: 45.0%

1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester (78061-46-8) → methyl cis-1-benzoyl-1,2,3,4-tetrahydro-2-indol-3-ylpyridine-4-carboxylate (107183-32-4) + methyl 1-benzoyl-1,2,3,6-tetrahydro-2-indol-3-ylpyridine-4-carboxylate (107183-31-3)

Guidance literature:

With hydrogen; palladium carbon; In tetrahydrofuran; for 3h; Ambient temperature;

Reference yield:

1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridine-4-carboxylic acid methyl ester (78061-46-8) → methyl cis-1-benzoyl-2-indol-3-ylpiperidine-4-carboxylate (107183-29-9,107183-30-2) + methyl trans-1-benzoyl-2-indol-3-ylpiperidine-4-carboxylate (107183-29-9,107183-30-2)

Guidance literature:

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; for 3.5h; Ambient temperature;

upstream raw materials:

indole

4-pyridinecarboxylic acid, methyl ester

benzoyl chloride

Downstream raw materials:

methyl cis-1-benzoyl-1,2,3,4-tetrahydro-2-indol-3-ylpyridine-4-carboxylate

methyl 1-benzoyl-1,2,3,6-tetrahydro-2-indol-3-ylpyridine-4-carboxylate

methyl cis-1-benzoyl-2-indol-3-ylpiperidine-4-carboxylate

methyl trans-1-benzoyl-2-indol-3-ylpiperidine-4-carboxylate

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