(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

Base Information

Chemical Name:(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide
CAS No.:185508-88-7
Molecular Formula:C₁₆H₂₈N₂O₂Si
Molecular Weight:308.496
Hs Code.:

Synonyms:(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

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Chemical Property of (S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

Chemical Property:

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Technology Process of (S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

There total 3 articles about (S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18243-41-9
(bromomethyl)trimethylsilane

: 170115-96-5
2-amino-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylacetamide

: (R)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

: 185508-88-7
(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

Guidance literature:: With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at 23 ℃; for 22h; Yield given. Yields of byproduct given;
DOI:10.1021/ja9624073

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 185508-88-7
(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi, LiCl / hexane; tetrahydrofuran / 1 h / 0 °C

2: n-BuLi, LiCl / tetrahydrofuran; hexane / 22 h / 23 °C

With n-butyllithium; lithium chloride; In tetrahydrofuran; hexane;
DOI:10.1021/ja9624073

Reference yield:

: 185508-77-4
{[((1S,2S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-methyl}-carbamic acid tert-butyl ester

: 185508-88-7
(S)-2-Amino-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-3-trimethylsilanyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / HCl / methanol / 3 h / 0 °C / other solvent, reagent

2: n-BuLi, LiCl / tetrahydrofuran; hexane / 22 h / 23 °C

With hydrogenchloride; n-butyllithium; lithium chloride; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/ja9624073