3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI)

Base Information

Chemical Name:3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI)
CAS No.:412299-21-9
Molecular Formula:C₁₀H₁₄O₅
Molecular Weight:214.218
Hs Code.:
Mol file:412299-21-9.mol

Synonyms:3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI)

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Chemical Property of 3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI)

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Technology Process of 3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI)

There total 2 articles about 3-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-2-propyl-, ethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1-ethoxy-1,3-bis(trimethylsilyloxy)hex-1-ene

: 79-37-8
oxalyl dichloride

: 412299-21-9
ethyl 4-hydroxy-2-propyl-5-oxo-2,5-dihydrofuran-3-carboxylate

Guidance literature:: In dichloromethane; at -78 - 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2005.09.137

Reference yield:

: 2305-25-1
3-hydroxy-hexanoic acid ethyl ester

: 412299-21-9
ethyl 4-hydroxy-2-propyl-5-oxo-2,5-dihydrofuran-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: nBuLi; diisopropylamine / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 24 h / -78 - 20 °C

2.1: 71 percent / CH₂Cl₂ / 18 h / -78 - 20 °C

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/j.tetlet.2005.09.137