2-(4-fluorophenyl)-2-hydroxyiminoacetic acid

Base Information

• Chemical Name: 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid
• CAS No.: 1353886-53-9
• Molecular Formula: C₈H₆FNO₃
• Molecular Weight: 183.139
• Mol file: 1353886-53-9.mol

Synonyms:2-(4-fluorophenyl)-2-hydroxyiminoacetic acid

Chemical Property of 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid

There total 2 articles about 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl 2-(4-fluorophenyl)-2-(hydroxyimino)acetate (1379588-33-6) → 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid (1353886-53-9)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃;

DOI:10.1016/j.tet.2014.10.053

Reference yield:

fluorobenzene (462-06-6) → 2-(4-fluorophenyl)-2-hydroxyiminoacetic acid (1353886-53-9)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / 7 h / -15 °C / Inert atmosphere

2: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

With trifluorormethanesulfonic acid; lithium hydroxide; In tetrahydrofuran; methanol; water;

DOI:10.1016/j.tet.2014.10.053

Reference yield: 89.0%

2-(4-fluorophenyl)-2-hydroxyiminoacetic acid (1353886-53-9) → (2RS)-N-(p-fluorophenyl)glycine (7292-73-1)

Guidance literature:

With sodium tetrahydroborate; nickel; sodium hydroxide; In methanol; water; at 20 - 30 ℃;

DOI:10.1039/c1ob06471a

upstream raw materials:

ethyl 2-(4-fluorophenyl)-2-(hydroxyimino)acetate

fluorobenzene

Downstream raw materials:

(2RS)-N-(p-fluorophenyl)glycine

Refernces