N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 220079-71-0
• Molecular Formula: C₂₃H₃₁N₃O₅S
• Molecular Weight: 461.582
• Mol file: 220079-71-0.mol

Synonyms:N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester

Chemical Property of N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester

There total 5 articles about N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

N-Ethyl-N'-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid tert-butyl ester (220079-68-5) + benzyl alcohol (100-51-6,185532-71-2) → N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester (220079-71-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;

DOI:10.1055/s-1998-2217

Reference yield:

1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine (127799-53-5) → N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester (220079-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃, Bu₄NHSO₄, NaOH / benzene / 30 h / Ambient temperature

2: 89 percent / H₂ / 5percent Pd/C / methanol

3: 97 percent / CH₂Cl₂

4: 79 percent / Ph₃P, DEAD / tetrahydrofuran

With sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; benzene;

DOI:10.1055/s-1998-2217

Reference yield:

1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine (220079-14-1) → N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester (220079-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / H₂ / 5percent Pd/C / methanol

2: 97 percent / CH₂Cl₂

3: 79 percent / Ph₃P, DEAD / tetrahydrofuran

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1055/s-1998-2217

upstream raw materials:

N-Ethyl-N'-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid tert-butyl ester

benzyl alcohol

Tosyl isocyanate

1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine