1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine

Base Information

• Chemical Name: 1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine
• CAS No.: 220079-14-1
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 220079-14-1.mol

Synonyms:1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine

Chemical Property of 1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine

There total 1 articles about 1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl iodide (75-03-6) + 1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine (127799-53-5) → 1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine (220079-14-1)

Guidance literature:

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In benzene; for 30h; Ambient temperature;

DOI:10.1055/s-1998-2217

Reference yield:

1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine (220079-14-1) → N-Ethyl-N'-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid tert-butyl ester (220079-68-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / H₂ / 5percent Pd/C / methanol

2: 97 percent / CH₂Cl₂

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1055/s-1998-2217

Reference yield:

1-(benzyloxycarbonyl)-2-(tert-butoxycarbonyl)-2-ethyl-1-methylhydrazine (220079-14-1) → N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester (220079-71-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / H₂ / 5percent Pd/C / methanol

2: 97 percent / CH₂Cl₂

3: 79 percent / Ph₃P, DEAD / tetrahydrofuran

With hydrogen; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1055/s-1998-2217

upstream raw materials:

ethyl iodide

1-[(1,1-dimethylethoxy)carbonyl]-2-[(phenylmethoxy)carbonyl]-2-methylhydrazine

Downstream raw materials:

N'-Ethyl-N'-(4-fluoro-benzoyl)-N-methyl-hydrazinecarboxylic acid benzyl ester

N-Ethyl-N'-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid tert-butyl ester

N'-Ethyl-N-methyl-N'-(toluene-4-sulfonylaminocarbonyl)-hydrazinecarboxylic acid benzyl ester

N'-[Benzyl-(toluene-4-sulfonyl)-aminocarbonyl]-N-ethyl-N'-methyl-hydrazinecarboxylic acid tert-butyl ester