(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

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Chemical Name:(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide
CAS No.:1311378-54-7
Molecular Formula:C₂₃H₂₂F₃NO
Molecular Weight:385.429
Hs Code.:

Synonyms:(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

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Chemical Property of (E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

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Technology Process of (E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

There total 4 articles about (E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1311378-40-1
(E)-4-(trifluoromethyl)benzaldehyde O-[3-cyclohexyl-1-phenylprop-2-yn-1-yl]oxime

: 1311378-54-7
(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: C₂₃H₂₂F₃NO

Guidance literature:: With [CuCl(cod)]2; In acetonitrile; at 70 ℃; for 168h; optical yield given as %de; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol2012583

Reference yield:

: 872885-05-7,128812-16-8
1-phenyl-3-cyclohexyl-prop-2-yn-1-ol

: 1311378-54-7
(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

3: tetrahydrofuran / 2 h / 65 °C

4: [CuCl(cod)]2 / acetonitrile / 168 h / 70 °C / Inert atmosphere

With [CuCl(cod)]2; di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1: Mitsunobu reaction;
DOI:10.1055/s-0031-1290819

Reference yield:

: C₂₃H₂₁NO₃

: 1311378-54-7
(E)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

: (Z)-3-benzylidene-4-cyclohexyl-2-(4-(trifluoromethyl)phenyl)-2,3-dihydroazete 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 2 h / 65 °C

3: [CuCl(cod)]2 / acetonitrile / 168 h / 70 °C / Inert atmosphere

With [CuCl(cod)]2; hydrazine hydrate; In tetrahydrofuran; acetonitrile;
DOI:10.1055/s-0031-1290819