2-PHENYL-ACETIMIDIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-PHENYL-ACETIMIDIC ACID ETHYL ESTER
• CAS No.: 4971-77-1
• Molecular Formula: C10H13 N O
• Molecular Weight: 163.219
• Hs Code.: 2925290090
• Mol file: 4971-77-1.mol

Synonyms:Acetimidicacid, 2-phenyl-, ethyl ester (7CI,8CI); Acetimidic acid, phenyl-, ethyl ester(6CI); 2-Phenylacetimidic acid ethyl ester; Ethyl 2-phenylacetimidate; Ethylphenylacetimidate

Chemical Property of 2-PHENYL-ACETIMIDIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 96-98.5 °C(Press: 2 Torr)
• PKA: 8.12±0.70(Predicted)
• PSA: 33.08000
• Density: 0.97±0.1 g/cm3(Predicted)
• LogP: 2.34260

Purity/Quality:

98%Min ^*data from raw suppliers

ETHYL-2-PHENYLACETIMIDATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-ACETIMIDIC ACID ETHYL ESTER

There total 4 articles about 2-PHENYL-ACETIMIDIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + phenylacetonitrile (140-29-4) → ethyl 2-phenylethanimidoate (4971-77-1)

Guidance literature:

With acetyl chloride; at 25 ℃; for 6h;

DOI:10.1002/ejoc.200400591

Reference yield:

ethyl 2-phenylacetimidate hydrochloride (5442-34-2) → ethyl 2-phenylethanimidoate (4971-77-1)

Guidance literature:

With Amberlyst A-21 resin; In acetonitrile; for 0.25h;

DOI:10.2174/138620711794474033

Reference yield:

phenylacetonitrile (140-29-4) → ethyl 2-phenylethanimidoate (4971-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 0.08 h / 0 °C / Inert atmosphere

2: Amberlyst A-21 resin / acetonitrile / 0.25 h

With hydrogenchloride; In acetonitrile; 1: Pinner reaction;

DOI:10.2174/138620711794474033

upstream raw materials:

ethanol

phenylacetonitrile

ethyl 2-phenylacetimidate hydrochloride

Downstream raw materials:

2-benzyl-3a,4,5,6,7,7a-hexahydro-1H-benzimidazole

phenyl-acetaldehyde-(benzyl-phenyl-hydrazone)

tolazoline

N-phenylphenylacetamidine