4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

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Chemical Name:4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester
CAS No.:1312612-75-1
Molecular Formula:C₂₇H₂₅NO₄
Molecular Weight:427.5
Hs Code.:

Synonyms:4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

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Chemical Property of 4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

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Technology Process of 4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

There total 6 articles about 4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 85-44-9
phthalic anhydride

: 1312612-74-0
4-[2-(4-aminophenyl)ethyl]benzoic acid tert-butyl ester

: 1312612-75-1
4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

Guidance literature:: at 200 ℃; for 1h; Neat (no solvent);
DOI:10.1016/j.bmc.2011.03.065

Reference yield:

: 1312612-73-9
4-[2-(4-nitrophenyl)ethenyl]benzoic acid tert-butyl ester

: 1312612-75-1
4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

2: 1 h / 200 °C / Neat (no solvent)

With palladium 10% on activated carbon; hydrogen; In ethyl acetate;
DOI:10.1016/j.bmc.2011.03.065

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 1312612-75-1
4-{2-[4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)phenyl]ethyl}benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / Reflux

2: 18-crown-6 ether; potassium carbonate / dichloromethane / Reflux

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

4: 1 h / 200 °C / Neat (no solvent)

With 18-crown-6 ether; palladium 10% on activated carbon; hydrogen; potassium carbonate; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmc.2011.03.065