4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

Base Information

Chemical Name:4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate
CAS No.:1207202-97-8
Molecular Formula:C₃₂H₃₁ClN₂O₅S₂
Molecular Weight:623.194
Hs Code.:

Synonyms:4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

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Chemical Property of 4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

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Technology Process of 4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

There total 5 articles about 4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56243-25-5
1-benzyl-4-cyano-4-phenylpiperidine

: 1207202-97-8
4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sulfuric acid / 1 h / 100 °C

1.2: Cooling with ice

2.1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

4.1: boron tribromide / dichloromethane / 20 °C / Cooling with ice

5.1: triethylamine / dichloromethane / 3 h / 20 °C

With sulfuric acid; water; boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 10147-36-1
n-propanesulfonyl chloride

: 1207203-56-2
1-{[5-(2-Chlorophenyl)-4-(4-hydroxyphenyl)thien-2-yl]carbonyl}-4-phenylpiperidine-4-carboxamide

: 1207202-97-8
4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 59084-07-0
1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide; hydrochloride

: 1207202-97-8
4-{5-[(4-carbamoyl-4-phenylpiperidin-1-yl)carbonyl]-2-(2-chlorophenyl)thien-3-yl}phenyl propane-1-sulphonate

Guidance literature:: Multi-step reaction with 4 steps

1: cyclohexa-1,3-diene / palladium 10% on activated carbon / methanol / 6 h / Reflux

2: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C

3: boron tribromide / dichloromethane / 20 °C / Cooling with ice

4: triethylamine / dichloromethane / 3 h / 20 °C

With boron tribromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; cyclohexa-1,3-diene; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;