1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid
CAS No.:960391-29-1
Molecular Formula:C₂₅H₃₃F₂N₃O₃
Molecular Weight:461.552
Hs Code.:

Synonyms:1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

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Chemical Property of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

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Technology Process of 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

There total 8 articles about 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 960391-27-9
methyl 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylate

: 960391-29-1
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

Guidance literature:: methyl 1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylate; With lithium hydroxide; water; In 1,4-dioxane; at 75 ℃; for 2h;

With potassium hydrogensulfate; In 1,4-dioxane; water; pH=5 - 6;

Reference yield:

: 809273-66-3
methyl {[(4,4-difluorocyclohexyl)methanol]amino}-3-nitrobenzoate

: 960391-29-1
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

2.1: dmap / dichloromethane / 4 h / 20 °C

3.1: acetic acid / 3 h / 150 °C / Microwave irradiation

4.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

4.2: pH 5 - 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

6.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 75 °C

6.2: pH 5 - 6

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 809273-65-2
(4,4-difluorocyclohexane)methylamine hydrochloride

: 960391-29-1
1-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

3.1: dmap / dichloromethane / 4 h / 20 °C

4.1: acetic acid / 3 h / 150 °C / Microwave irradiation

5.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

5.2: pH 5 - 6

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

7.1: lithium hydroxide; water / 1,4-dioxane / 2 h / 75 °C

7.2: pH 5 - 6

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;