N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

Base Information

Chemical Name:N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide
CAS No.:850450-17-8
Molecular Formula:C₃₀H₂₄F₃N₅O₃
Molecular Weight:559.547
Hs Code.:

Synonyms:N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

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Chemical Property of N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

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Technology Process of N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

There total 15 articles about N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 850451-78-4
N-[3-(7-chloro-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl)-4-methyl-phenyl]-3-trifluoromethyl-benzamide

: 850450-17-8
N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

Guidance literature:: With potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 14h;

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 850450-17-8
N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

3: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C

With potassium tert-butylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 6975-44-6
4,6-dihydroxynicotinic acid ethyl ester

: 850450-17-8
N-{3-[7-(6-methoxy-pyridin-3-ylamino)-1-methyl-2-oxo-1,2-dihydro-[1,6]naphthyridin-3-yl]-4-methyl-phenyl}-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate / 2 h / 110 °C

2: acetonitrile / 2.5 h / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 78 °C

4: manganese(IV) oxide / dichloromethane / 2 h / 20 °C

5: sodium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C

7: potassium tert-butylate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;