4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

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Chemical Name:4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid
CAS No.:1073135-61-1
Molecular Formula:C₂₈H₂₈FN₃O₅
Molecular Weight:505.546
Hs Code.:

Synonyms:4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

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Chemical Property of 4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

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Technology Process of 4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

There total 9 articles about 4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1073135-59-7
4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid methyl ester

: 1073135-61-1
4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

Guidance literature:: 4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid methyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1073135-61-1
4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: zinc(II) iodide / benzene / 1.58 h / 20 °C

2.1: diisopropylamine; n-butyllithium / hexane; 1,2-dimethoxyethane / 1 h / -60 °C

2.2: 4.33 h / -60 - 20 °C

2.3: 16 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

4.1: acetic anhydride / 0 °C

4.2: 24 h / 130 °C

5.1: trichlorophosphate / sulfolane / 1 h / 120 °C

5.2: 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

6.2: 16 h / Reflux

7.1: formic acid / palladium / methanol / 21 h / 20 °C / Inert atmosphere

8.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; tetrahydrofuran / 26 h / 70 - 80 °C

9.1: sodium hydroxide; water / 1,4-dioxane / 16 h / 20 °C

With n-butyllithium; formic acid; water; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; diisopropylamine; sodium hydroxide; zinc(II) iodide; trichlorophosphate; palladium; In tetrahydrofuran; 1,4-dioxane; sulfolane; methanol; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; mineral oil; benzene;

Reference yield:

: 84126-12-5
2-(2-fluorophenyl)-2-hydroxy-1-(4-methoxyphenyl)ethanone

: 1073135-61-1
4-[(3R)-3-{[6-(2-Fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperidin-1-yl]butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

2.1: acetic anhydride / 0 °C

2.2: 24 h / 130 °C

3.1: trichlorophosphate / sulfolane / 1 h / 120 °C

3.2: 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

4.2: 16 h / Reflux

5.1: formic acid / palladium / methanol / 21 h / 20 °C / Inert atmosphere

6.1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; tetrahydrofuran / 26 h / 70 - 80 °C

7.1: sodium hydroxide; water / 1,4-dioxane / 16 h / 20 °C

With formic acid; water; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; sodium hydroxide; trichlorophosphate; palladium; In tetrahydrofuran; 1,4-dioxane; sulfolane; methanol; N,N-dimethyl-formamide; mineral oil;