(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

Base Information

Chemical Name:(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine
CAS No.:187992-65-0
Molecular Formula:C₃₀H₃₀N₂O₄
Molecular Weight:482.579
Hs Code.:

Synonyms:(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

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Chemical Property of (2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

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Technology Process of (2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

There total 5 articles about (2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 74232-79-4
3-bromomethyl-1-ethoxycarbonylmethoxybenzene

: 187993-59-5
(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine

: 187992-65-0
(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.076

Reference yield:

: 74232-79-4
3-bromomethyl-1-ethoxycarbonylmethoxybenzene

: 584-08-7
potassium carbonate

: 187993-59-5
(2R)-2-(4,5-diphenyloxazol-2-yl)pyrrolidine

: 187992-65-0
(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield:

: (R)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(2-oxo-1,2-diphenyl-ethyl) ester

: 187992-65-0
(2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / AcONH₄; AcOH

2: 98 percent / H₂ / Pd/C / methanol

3: 95 percent / K₂CO₃ / dimethylformamide

With ammonium acetate; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2006.06.076