187993-59-5

Upstream product

• 328000-82-4 (R)-4-Chloro-1-(4,5-diphenyl-oxazol-2-yl)-butylamine 
• 187993-58-4 (2R)-1-benzyloxycarbonyl-2-(4,5-diphenyloxazol-2-yl)pyrrolidine 
• 6404-31-5 Z-D-proline 
• 33162-00-4 2-Aminomethyl-4,5-diphenyl-1,3-oxazole 
• 328000-89-1 4,5-Diphenyl-2-phthalimidomethyl-1,3-oxazole 
• 328000-43-7 (1S,2S,5S)-3-(4,5-Diphenyl-1,3-oxazol-2-ylmethylimino)-2,6,6-trimethylbicyclo[3.1.1]heptan-2-ol 
• 328000-71-1 (1S,2S,5S)-3-[(E)-(R)-4-Chloro-1-(4,5-diphenyl-oxazol-2-yl)-butylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol 
• 81819-14-9 (4,5-diphenyloxazol-2-yl)methyl bromide 

Downstream Products

• 187992-65-0 (2R)-2-(4,5-diphenyloxazol-2-yl)-1-(3-ethoxycarbonylmethoxybenzyl)pyrrolidine 

Relevant academic research and scientific papers

Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: Orally active prostacyclin mimetics. Part 6

The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157 is described. SAR studies to replace the cyclohexene-linker of FR181157 led to the discovery of compound 1i (FR207845) as a potent non-prost

4,5-dipheny-oxazole derivatives and their use as platelet aggregation inhibitors

Heterocyclic compounds of the formula: ???whereinR1 is carboxy or esterified carboxy,R2 is phenyl or (C1-C6)alkylphenyl,R3 is phenyl or (C1-C6)alkylphenyl,R4 is hydrog

Asymmetric synthesis of 2-(α-aminoalkyl)oxazoles, 2-oxazolylpyrrolidines, 2-oxazolylpiperidines: Total synthesis of 4,5-dihydroxypipecolinic acid

Asymmetric α-alkylation of 2-aminomethyl-4,5-diphenyloxazole was achieved by formation of azomethines 1 and ent-1 with the enantiomers of 2-hydroxypinan-3-one as chiral auxiliaries, reaction with alkylating reagents and final removal of the chiral auxiliary giving rise to optically active 2-(α-aminoalkyl)oxazoles 3, ent-3, 6 and 9. If α,ω-dihaloalkanes were used the resulting alkylation products could be further cyclized by intramolecular alkylation of the amino group to afford optically active 2-oxazolyl-N-heterocycles 4, ent-4, 7 and 10. The latter could be used for the total synthesis of naturally occurring 4,5-dihydroxypipecolinic acid 13.

4,5-diaryl oxazole derivatives

This invention relates to new heterocyclic compounds, compositions, process of making and method of use thereof for inhibition of platelet aggregation, vasodilation, antihypertensive activity and prostaglandin I2 agonist.