2-bromo-N-(4-bromo-3-methylphenyl)acetamide

Base Information

• Chemical Name: 2-bromo-N-(4-bromo-3-methylphenyl)acetamide
• CAS No.: 349121-12-6
• Molecular Formula: C₉H₉Br₂NO
• Molecular Weight: 306.985
• DSSTox Substance ID: DTXSID901261868

Synonyms:2-bromo-N-(4-bromo-3-methylphenyl)acetamide;349121-12-6;SCHEMBL4003419;QXOXFFMJODGJDV-UHFFFAOYSA-N;DTXSID901261868;MFCD02974394;AKOS008971430;CS-0327634

Chemical Property of 2-bromo-N-(4-bromo-3-methylphenyl)acetamide

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 306.90304
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)NC(=O)CBr)Br

Technology Process of 2-bromo-N-(4-bromo-3-methylphenyl)acetamide

There total 2 articles about 2-bromo-N-(4-bromo-3-methylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

amino-5-bromo-2-toluene (6933-10-4) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-(4-bromo-3-methylphenyl)acetamide (349121-12-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.6b00245

Reference yield: 71.0%

2-bromoacetyl chloride (22118-09-8) + amino-5-bromo-2-toluene (6933-10-4) → 2-bromo-N-(4-bromo-3-methylphenyl)acetamide (349121-12-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2004.07.068

Reference yield: 77.0%

2-(piperazin-1-yl)benzonitrile (111373-03-6) + 2-bromo-N-(4-bromo-3-methylphenyl)acetamide (349121-12-6) → N-(4-bromo-3-methylphenyl)-2-[4-(2-cyanophenyl)-1-piperazinyl]acetamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In toluene; at 60 ℃;

DOI:10.1016/j.bmcl.2004.07.068

upstream raw materials:

2-bromoacetyl chloride

amino-5-bromo-2-toluene

2-Bromoacetyl bromide

Downstream raw materials:

2-[4-(4-bromo-2-cyano-phenyl)-piperazin-1-yl]-N-(4-bromo-3-methyl-phenyl)-acetamide

2-((1H-benzo[d]imidazol-2-yl)thio)-N-(4-bromo-3-methylphenyl)acetamide

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