1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

Base Information

Chemical Name:1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose
CAS No.:204588-70-5
Molecular Formula:C₄₇H₄₉NO₈
Molecular Weight:755.908
Hs Code.:

Synonyms:1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

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Chemical Property of 1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

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Technology Process of 1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

There total 8 articles about 1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1738-68-7
Gly-OBz

: 204588-67-0
1-[7-carboxy-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

: 204588-70-5
1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1016/S0968-0896(98)80017-5

Reference yield: 66.0%

: 2462-31-9
benzyl 2-aminoacetate hydrochloride

: 204588-67-0
1-[7-carboxy-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

: 204588-70-5
1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(98)00468-7

Reference yield:

: 144464-65-3
7-Trifluoromethanesulphonyloxy-1,2,3,4-tetrahydronaphthalen-1-one

: 204588-70-5
1-[7-(N-(benzyloxycarbonylmethyl)-aminocarbonyl)-1,2,3,4-tetrahydro-1(R,S)-naphthyl]-2,3,4-tri-O-benzyl-α-L-fucopyranose

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 1,3-bis(diphenylphosphino)propane; triethylamine / palladium(II) acetate / dimethylformamide

2: 80 percent / sodium borohydride / methanol / 1 h

3: 61 percent / tetraethylammonium bromide; 4 Angstroem molecular sieves / CH₂Cl₂ / 24 h / 20 °C

4: 92 percent / LiOH / tetrahydrofuran; H₂O / 24 h / Heating

5: 66 percent / BOP-Cl; triethylamine / CH₂Cl₂ / 2.5 h / 20 °C

With lithium hydroxide; sodium tetrahydroborate; 4 A molecular sieve; 1,3-bis-(diphenylphosphino)propane; tetraethylammonium bromide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Carbonylation / 2: Reduction / 3: Condensation / 4: Hydrolysis / 5: Condensation;
DOI:10.1016/S0968-0896(98)80017-5