4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

Base Information

• Chemical Name: 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine
• CAS No.: 117323-27-0
• Molecular Formula: C₂₀H₂₂N₄O₂S
• Molecular Weight: 382.486
• Mol file: 117323-27-0.mol

Synonyms:4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

Chemical Property of 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

There total 6 articles about 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-morpholinobenzyl chloride (110405-99-7) + 1-(3-Methoxy-pyridin-2-yl)-1,3-dihydro-imidazole-2-thione (117296-71-6) → 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine (117323-27-0)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 0 ℃; for 3h;

DOI:10.1021/jm950610n

Reference yield:

3-methoxypyridin-2-amine (10201-71-5) → 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine (117323-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 18 h / Heating

2: AcOH, HCl / 18 h / Heating

3: NaOH / dimethylformamide / 3 h / 0 °C

With hydrogenchloride; sodium hydroxide; acetic acid; In N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm950610n

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → 4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine (117323-27-0)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran

3: SOCl₂ / CHCl₃

4: NaOH / dimethylformamide / 3 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm950610n

upstream raw materials:

2-morpholinobenzyl chloride

1-(3-Methoxy-pyridin-2-yl)-1,3-dihydro-imidazole-2-thione

3-methoxypyridin-2-amine

methyl 2-fluorobenzoate