2-morpholinobenzyl chloride

Base Information

• Chemical Name: 2-morpholinobenzyl chloride
• CAS No.: 110405-99-7
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.691
• Mol file: 110405-99-7.mol

Synonyms:2-morpholinobenzyl chloride

Chemical Property of 2-morpholinobenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-morpholinobenzyl chloride

There total 3 articles about 2-morpholinobenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-morpholin-4-ylphenyl)methanol (465514-33-4) → 2-morpholinobenzyl chloride (110405-99-7)

Guidance literature:

With thionyl chloride; In chloroform;

DOI:10.1021/jm950610n

Reference yield:

methyl 2-fluorobenzoate (394-35-4) → 2-morpholinobenzyl chloride (110405-99-7)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / Ambient temperature

2: LiAlH₄ / tetrahydrofuran

3: SOCl₂ / CHCl₃

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm950610n

Reference yield:

methyl 2-morpholinobenzoate (223560-37-0) → 2-morpholinobenzyl chloride (110405-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran

2: SOCl₂ / CHCl₃

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; chloroform;

DOI:10.1021/jm950610n

upstream raw materials:

(2-morpholin-4-ylphenyl)methanol

methyl 2-fluorobenzoate

methyl 2-morpholinobenzoate

Downstream raw materials:

4-[2-(1-Pyridin-2-yl-1H-imidazol-2-ylsulfanylmethyl)-phenyl]-morpholine

4-{2-[1-(3-Methyl-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

4-{2-[1-(3-Methoxy-pyridin-2-yl)-1H-imidazol-2-ylsulfanylmethyl]-phenyl}-morpholine

2-(2-Morpholin-4-yl-benzylsulfanyl)-1-pyridin-2-yl-1,4,5,6-tetrahydro-cyclopentaimidazole