Technology Process of 2,3,4,5-tetramethoxy-6-methylstyrene
There total 4 articles about 2,3,4,5-tetramethoxy-6-methylstyrene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
sodium amide;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
Inert atmosphere;
2,3,4,5-tetramethoxy-6-methyl benzaldehyde;
In
tetrahydrofuran;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1016/j.tet.2011.06.026
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide / ethanol; water / 0.75 h / Cooling with ice
2.1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C
2.2: 0.17 h / Cooling with ice
3.1: sodium amide / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
3.2: 24 h / 20 °C / Inert atmosphere
With
titanium tetrachloride; sodium amide; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2011.06.026
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium borohydride / methanol / 0.17 h / 0 °C
2.1: sodium hydroxide / ethanol; water / 0.75 h / Cooling with ice
3.1: titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C
3.2: 0.17 h / Cooling with ice
4.1: sodium amide / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere
4.2: 24 h / 20 °C / Inert atmosphere
With
potassium borohydride; titanium tetrachloride; sodium amide; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2011.06.026
