(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Base Information

Chemical Name:(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid
CAS No.:1202575-68-5
Molecular Formula:C₂₀H₂₁ClO₄
Molecular Weight:360.837
Hs Code.:

Synonyms:(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

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Chemical Property of (3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

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Technology Process of (3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

There total 5 articles about (3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1202577-86-3
Methyl (3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionate

: 1202575-68-5
(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: Methyl (3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 501334-19-6
methyl 3-[4-(tert-butyldimethylsilyloxybenzyl)phenyl]-3-oxopropanoate

: 1202575-68-5
(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; formic acid / Noyori's catalyst / 0 - 35 °C / Inert atmosphere

2: silver(l) oxide / toluene / 20 - 110 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

4: triphenylphosphine; diethylazodicarboxylate / toluene; water; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

5: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With formic acid; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; sodium hydroxide; silver(l) oxide; diethylazodicarboxylate; Noyori's catalyst; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 15115-59-0
4-chloro-2,3-dihydro-1H-inden-1-one

: 1202575-68-5
(3S)-3-(4-{[(1S)-4-chloro-2,3-dihydro-1H-inden-1-yl]oxy}phenyl)-3-ethoxypropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; formic acid / (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene) / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / toluene; water; tetrahydrofuran / 20 - 50 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With formic acid; water; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; (1S,2S)-N-p-toluenesulfonyl-1,2-diphenylethylenediamine-ruthenium(mesitylene); In tetrahydrofuran; methanol; dichloromethane; water; toluene;