15115-59-0

Basic information

• Product Name: 4-CHLORO-INDAN-1-ONE
• Synonyms: 4-CHLORO-INDAN-1-ONE;4-Chloro-1-Indanone;4-chloro-2,3-dihydroinden-1-one;4-Chloro-2,3-dihydro-1H-inden-1-one;4-choroindanone
• CAS NO: 15115-59-0
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.60428
• Product Categories: Indanone & Indene;API intermediates
• Mol File: 15115-59-0.mol

Chemical Properties

• Melting Point: 90-92℃
• Boiling Point: 285.8 °C at 760 mmHg
• Flash Point: 128.3 °C
• Appearance: White to yellow crystal or oil
• Density: 1.312 g/cm³
• Vapor Pressure: 0.00274mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CHLORO-INDAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-INDAN-1-ONE(15115-59-0)
• EPA Substance Registry System: 4-CHLORO-INDAN-1-ONE(15115-59-0)

Safety Data

• Hazardous Substances Data: 15115-59-0(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow crystal or oil

InChI:InChI=1/C9H7ClO/c10-8-3-1-2-7-6(8)4-5-9(7)11/h1-3H,4-5H2

Upstream product

• 107-94-8 chloropropionic acid 
• 108-90-7 chlorobenzene 
• 7446-70-0 aluminium trichloride 
• 51135-91-2 4-amino-2,3-dihydro-1H-inden-1-one 
• 24393-51-9 (E)-ethyl 2-chlorocinnamate 
• 3199-69-7 2-bromo-4-chloro-1-indanone 
• 1643-28-3 3-(2-chlorophenyl)propanoic acid 
• 1866-38-2 3-chlorocinnamic acid 
• 704-96-1 trans-2-chlorocinnamic acid 
• 89-98-5 2-chloro-benzaldehyde 
• 30573-88-7 ethyl 3-(2-chlorophenyl)propanoate 
• 75-15-0 carbon disulfide 
• 52085-97-9 3-(2-chlorophenyl)propionyl chloride 
• 201230-82-2 carbon monoxide 

Downstream Products

• 3199-71-1 4-chloro-2,3-dihydro-1H-inden-1-ol 
• 67120-40-5 4-chloroindane-1-amine 
• 13099-57-5 4-chloro-2,2-dimethyl-2,3-dihydro-1H-inden-1-one 
• 1003708-98-2 2-ethyl-4-chloro-1-indanone 
• 1338796-88-5 1-chloro-5,6,8,9-tetrahydrobenzocyclohepten-7-one 
• 1341187-31-2 2,2-bis(3,5-di-tert-butyl-4-hydroxybenzyl)-4-chloro-2,3-dihydroinden-1-one 
• 3199-69-7 2-bromo-4-chloro-1-indanone 
• 1188168-64-0 2,2-dibromo-4-chloro-1-indanone 

Relevant articles and documents

Synthesis of Conformationally Locked and C-Linked Analogues of Imidazole-Based Ketene Dithioacetal Fungicides

First examples with the unknown tricyclic 4,8 b -dihydro-3 aH -indeno[1,2- d ][1,3]dithiole ring system have been prepared. Also, imidazoles linked in ring position 5 to a ketene dithioacetal and 1,3-dithiane derivatives with an exocyclic cyano- and imidazole-substituted C-C double bond are completely new. All these compounds are either conformationally locked, C-linked or six-ring analogues of the antifungal agent luliconazole. Synthesis and fungicidal activity of these sterol biosynthesis inhibitors are reported.

CARBAMATE DERIVATIVE COMPOUNDS, PROCESSES FOR PREPARING THEM AND THEIR USES

The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention CNS disorders comprising administering a carbamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of CNS disorders.

Synthesis of 9H-Indeno [1, 2-b] pyrazine and 11H-indeno [1, 2-b] quinoxaline derivatives in one-step reaction from 2-bromo-4-chloro-1-indanone

The reaction of 2-bromo-4-chloro-1-indanone with 2, 3-diaminomaleonitrile, benzene-1, 2-diamine and 4-methylbenzene-1, 2-diamine in glacial acetic acid gave 8-chloro-9H-indeno[1, 2-b]pyrazine-2, 3-dicarbonitrile, 1-chloro-11H-indeno[1, 2-b]quinoxaline and

Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine

The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chlor

THERAPEUTIC FLUOROETHYLCYANO GUANIDINES

Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Synthesis of 1-indanones via intramolecular cyclodehydration of 3-arylpropionic acids catalyzed by heteropoly acid as heterogeneous catalyst

Intramolecular cyclodehydration of 3-arylpropionic acids catalyzed by heteropoly acids was investigated for the first time. Several 3-arylpropionic acids were refluxed and dehydrated in chlorobenzene in the presence of 0.2 equivalent of heteropoly acids, and 1-indanones were obtained in good yield. At the same time, intermolecular Friedel-Crafts acylation were observed in this experiment. Copyright Taylor & Francis Group, LLC.

Synthesis of 1-indanones by intramolecular Friedel-Crafts reaction of 3-arylpropionic acids catalyzed by Tb(OTf)3

Intramolecular Friedel-Crafts acylation reaction of 3-arylpropionic acids was efficiently catalyzed by Tb(OTf)3 at 250°C to give 1-indanones. Even deactivated 3-arylpropionic acids with halogen atoms on the aromatic ring can be cyclized in moderation to good yields.

4-SUBSTITUTED IMIDAZOLE-2-THIONES AND IMIDAZOL- 2-ONES AS AGONISTS OF THE ALPHA- 2B AND ALPHA-2C ADRENERGIC RECEPTORS

Compounds of Formula (I): where X is S and the variables have the meaning defined in the specification are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors, and as such have no or only minimal cardivascular and/or sedatory activity. These compounds of Formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2B adrenergic receptors. Compounds of Formula (I) where X is O also have the advantageous property that they have no or only minimal cardivascular and/or sedatory activity and are useful for treating pain and other conditions with no or only minimal cardivascular and/or sedatory activity.

Indanylidenes. 1. Design and synthesis of (E)-2-(4,6-difluoro-1-indanylidene)acetamide, a potent, centrally acting muscle relaxant with antiinflammatory and analgesic activity

The design of rigid cyclic analogues derived from cinnamamide 1, (E)-N-cyclopropyl-3-(3-fluorophenyl)prop-2-enamide, and β-methylcinnamamide 2, (E)-N-cyclopropyl-3-(3-fluorophenyl)but-2-enamide, has led to the discovery of the potent, centrally acting muscle relaxant (E)-2-(4,6-difluoro-1-indanylidene)acetamide, 17. Compound 17 also possesses potent antiinflammatory and analgesic activity. This paper describes the synthesis and the muscle relaxant, antiinflammatory, and analgesic structure-activity relationships of 17 and 67 of its analogues. Compound 17 has been taken into phase I clinical trials.