5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

Base Information

Chemical Name:5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol
CAS No.:1414932-58-3
Molecular Formula:C₂₃H₂₀N₄O
Molecular Weight:368.438
Hs Code.:

Synonyms:5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

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Chemical Property of 5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

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Technology Process of 5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

There total 3 articles about 5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.3%

: 1210-35-1
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one

: 79344-08-4
1-benzyl-5-bromo-1H-tetrazole

: 1414932-58-3
5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

Guidance literature:: 1-benzyl-5-bromo-1H-tetrazole; With isopropylmagnesium chloride; In tetrahydrofuran; at -24 - -20 ℃; for 0.333333h; Inert atmosphere;

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-one; In tetrahydrofuran; at -20 - 0 ℃; for 3.16h; Inert atmosphere;

With acetic acid; In tetrahydrofuran; Inert atmosphere;
DOI:10.1055/s-0032-1316737

Reference yield:

: 100-46-9
benzylamine

: 1414932-58-3
5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium azide; acetic acid / 17 h / 80 °C

2.1: acetic acid; N-Bromosuccinimide / 6 h / 80 °C

3.1: isopropylmagnesium chloride / tetrahydrofuran / 0.33 h / -24 - -20 °C / Inert atmosphere

3.2: 3.16 h / -20 - 0 °C / Inert atmosphere

3.3: Inert atmosphere

With N-Bromosuccinimide; sodium azide; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1055/s-0032-1316737

Reference yield:

: 6926-50-7
1-benzyl-1H-tetrazole

: 1414932-58-3
5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; N-Bromosuccinimide / 6 h / 80 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.33 h / -24 - -20 °C / Inert atmosphere

2.2: 3.16 h / -20 - 0 °C / Inert atmosphere

2.3: Inert atmosphere

With N-Bromosuccinimide; isopropylmagnesium chloride; acetic acid; In tetrahydrofuran;
DOI:10.1055/s-0032-1316737