79344-08-4

Basic information

• Product Name: 1H-Tetrazole, 5-bromo-1-(phenylmethyl)-
• CAS NO: 79344-08-4
• Molecular Formula: C8H7BrN4
• Molecular Weight: 239.074
• Mol File: 79344-08-4.mol

Chemical Properties

• CAS DataBase Reference: 1H-Tetrazole, 5-bromo-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Tetrazole, 5-bromo-1-(phenylmethyl)-(79344-08-4)
• EPA Substance Registry System: 1H-Tetrazole, 5-bromo-1-(phenylmethyl)-(79344-08-4)

Safety Data

• Hazardous Substances Data: 79344-08-4(Hazardous Substances Data)

Upstream product

• 506-68-3 bromocyane 
• 622-79-7 benzyl azide 
• 6926-50-7 1-benzyl-1H-tetrazole 
• 100-46-9 benzylamine 

Downstream Products

• 88104-34-1 1-benzyl-N-phenyl-1H-tetrazol-5-amine 
• 66907-78-6 5-benzylamino-1-benzyltetrazole 
• 28386-90-5 5-benzyl-1-phenyl-1H-tetrazole 
• 88104-45-4 1-benzyl-N-(4-nitrophenyl)-1H-tetrazol-5-amine 
• 88104-46-5 5-(2-nitrophenyl)amino-1-benzyl tetrazole 
• 1260599-33-4 4-(1-benzyl-1H-tetrazol-5-yloxy)benzaldehyde 
• 1414932-57-2 (1-benzyl-1H-tetrazol-5-yl)diphenylmethanol 
• 164589-82-6 1-(1-benzyl-1H-tetrazol-5-yl)(phenyl)methanol 
• 1414932-58-3 5-[1-(benzyl)-1H-tetrazol-5-yl]-10,11-dihydro-5H-dibenzo[α,δ]cyclohepten-5-ol 
• 1414932-59-4 1-(1-benzyl-1H-tetrazol-5-yl)-1,2,3,4-tetrahydronaphthalen-1-ol 
• 1414932-60-7 1-(1-benzyl-1H-tetrazol-5-yl)-1-phenylethanol 
• 54347-27-2 1-(1-benzyl-1H-tetrazol-5-yl)cyclohexanol 
• 120869-85-4 (1-benzyl-1H-tetrazol-5-yl)phenylketone 
• 6926-50-7 1-benzyl-1H-tetrazole 

Relevant articles and documents

METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS

Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment, comprising inhibiting aminolevulinic acid synthase 2 (ALAS2) in the subject by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Disorders that are of particular interest are blood disorders, such as porphyria and anemia.

Some practical methods for the application of 5-metallo-1-benzyl-1H- tetrazoles in synthesis

Nucleophilic reagents such as 5-lithiotetrazoles are synthetically powerful tools for the installation of tetrazole functional groups, but they are of limited utility due to the instability of tetrazole-derived carbanions. Herein, we report practical methods for the generation and use of new 5-metallo-1-benzyl-1H-tetrazoles (M=K, MgX, ZnX) derived from either 1-benzyl-1H-tetrazole or 1-benzyl-5-bromo-1H-tetrazole. By varying the metal counterion, the tetrazole carbanion stability was improved. Potassium- and magnesium-derived reagents underwent additions to carbonyl compounds at -30 and -20°C, respectively. The isolated yields (41-85%) from these and other reactions were comparable to those reported for 5-lithiotetrazoles at much lower temperatures (-78 to -98 °C). Georg Thieme Verlag Stuttgart ? New York.

METHOD FOR THE PRODUCTION OF SUBSTITUTED AZOLES

Disclosed is a method for producing substituted azoles. Said method makes it possible to produce compounds of general formula (I) and/or the salts thereof and/or the acid addition compounds thereof, wherein the substituents R1 and R2, A, and B have the me