2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Base Information

Chemical Name:2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile
CAS No.:181579-47-5
Molecular Formula:C₂₂H₂₉N₅
Molecular Weight:363.506
Hs Code.:

Synonyms:2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

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Technology Process of 2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

There total 5 articles about 2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 7677-24-9
trimethylsilyl cyanide

: 67-64-1
acetone

: 163276-82-2
4--1-(phenylmethyl)piperidine

: 181579-47-5
2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: With zinc(II) chloride;
DOI:10.1021/jm960158n

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 181579-47-5
2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃ / acetonitrile / 120 h / Ambient temperature

2: 100 percent / TiCl₃, aq. HCl / 21 h / Ambient temperature

3: 85 percent / ZnCl₂

With hydrogenchloride; titanium(III) chloride; potassium carbonate; zinc(II) chloride; In acetonitrile;
DOI:10.1021/jm960158n

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 181579-47-5
2-{2-[(1-Benzyl-piperidin-4-yl)-methyl-amino]-pyridin-3-ylamino}-2-methyl-propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / sodium cyanoborohydride, 4 Angstroem molecular sieves / methanol / 24 h / Ambient temperature

2: 95 percent / K₂CO₃ / acetonitrile / 120 h / Ambient temperature

3: 100 percent / TiCl₃, aq. HCl / 21 h / Ambient temperature

4: 85 percent / ZnCl₂

With hydrogenchloride; titanium(III) chloride; 4 A molecular sieve; sodium cyanoborohydride; potassium carbonate; zinc(II) chloride; In methanol; acetonitrile;
DOI:10.1021/jm960158n