(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

Base Information

Chemical Name:(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione
CAS No.:1197396-88-5
Molecular Formula:C₂₄H₂₈FN₅O₂
Molecular Weight:437.517
Hs Code.:

Synonyms:(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

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Chemical Property of (1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

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Technology Process of (1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

There total 4 articles about (1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(3-fluorophenyl)amino]ethyl methanesulfonate

: 1075237-77-2
(1R)-1-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

: 1197396-88-5
(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

Guidance literature:: (1R)-1-[(4-amino-1-piperidinyl)methyl]-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione; With potassium carbonate; In methanol; acetonitrile; at 20 ℃; for 0.166667h;

2-[(3-fluorophenyl)amino]ethyl methanesulfonate; In methanol; acetonitrile; at 20 - 80 ℃; for 47h; Inert atmosphere;

Reference yield:

: 2-[(3-fluorophenyl)amino]ethyl chloridocarbonate

: 1197396-88-5
(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol / 2 h / 90 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 h / 0 - 20 °C

3.1: potassium carbonate / methanol; acetonitrile / 0.17 h / 20 °C

3.2: 47 h / 20 - 80 °C / Inert atmosphere

With potassium carbonate; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 372-19-0
meta-fluoroaniline

: 1197396-88-5
(1R)-1-{[4-({2-[(3-fluorophenyl)amino]ethyl}amino)-1-piperidinyl]methyl}-1,2-dihydro-4H,9H-imidazo[1,2,3-ij]-1,8-naphthyridine-4,9-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol / 2 h / 90 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

3.2: 20 h / 0 - 20 °C

4.1: potassium carbonate / methanol; acetonitrile / 0.17 h / 20 °C

4.2: 47 h / 20 - 80 °C / Inert atmosphere

With pyridine; potassium carbonate; triethylamine; potassium hydroxide; In methanol; ethanol; dichloromethane; acetonitrile;