(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

Base Information

Chemical Name:(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester
CAS No.:190127-10-7
Molecular Formula:C₁₄H₂₀NO₂P
Molecular Weight:265.292
Hs Code.:

Synonyms:(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

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Chemical Property of (1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

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Technology Process of (1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

There total 3 articles about (1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 16391-06-3
methyl hypophosphorous acid methyl ester

: 143427-63-8
1-Benzyl-4-iodo-1,2,5,6-tetrahydropyridine

: 190127-10-7
(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 80 - 90 ℃; for 1h;
DOI:10.1016/0960-894X(96)00364-2

Reference yield:

: 107301-61-1
N-benzyl-4-amino-1-butyne

: 190127-10-7
(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / NaI, RSO₃H / H₂O

2: 53 percent / Pd(PPh₃)4, DABCO / toluene / 1 h / 80 - 90 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium iodide; In water; toluene;
DOI:10.1016/0960-894X(96)00364-2

Reference yield:

: 100-46-9
benzylamine

: 190127-10-7
(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methyl-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MsCl, Et₃N, 2.) NaI / 1.) CH₂Cl₂, 2.) DMSO

2: 81 percent / NaI, RSO₃H / H₂O

3: 53 percent / Pd(PPh₃)4, DABCO / toluene / 1 h / 80 - 90 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; methanesulfonyl chloride; triethylamine; sodium iodide; In water; toluene;
DOI:10.1016/0960-894X(96)00364-2