3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione

Base Information

Chemical Name:3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione
CAS No.:124482-69-5
Molecular Formula:C₁₃H₁₄ClNO₂
Molecular Weight:251.713
Hs Code.:
ChEMBL ID:CHEMBL172754
DSSTox Substance ID:DTXSID701206909
Nikkaji Number:J274.883E

Synonyms:CHEMBL172754;DTXSID701206909;124482-69-5;3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione

Suppliers and Price of 3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:251.0713064
Heavy Atom Count:17
Complexity:311

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C(=O)CCC(C1=O)CC2=CC=C(C=C2)Cl

Technology Process of 3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione

There total 2 articles about 3-[(4-Chlorophenyl)methyl]-1-methyl-2,6-piperidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24866-79-3
3-(4-chloro-benzyl)-piperidine-2,6-dione

: 74-88-4
methyl iodide

: 124482-69-5
3-(4-Chloro-benzyl)-1-methyl-piperidine-2,6-dione

Guidance literature:: With potassium hydroxide; In acetone; Heating;
DOI:10.1021/jm00165a007

Reference yield:

: 1121-89-7
piperidine-2,6-dione

: 124482-69-5
3-(4-Chloro-benzyl)-1-methyl-piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na/liquid NH₃, Fe(NO₃)3*9H₂O / 1.) 30 min, 2.) ether, 1 h

2: 67 percent / KOH / acetone / Heating

With potassium hydroxide; ammonia; sodium; In acetone;
DOI:10.1021/jm00165a007