2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine

Base Information

• Chemical Name: 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine
• CAS No.: 1313885-05-0
• Molecular Formula: C₁₈H₂₄ClN
• Molecular Weight: 289.848
• Mol file: 1313885-05-0.mol

Synonyms:2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine

Chemical Property of 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine

There total 1 articles about 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

myrtenal (564-94-3,18486-69-6) + 4-chlorophenylethylamine (156-41-2) → 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine (1313885-05-0)

Guidance literature:

myrtenal; 4-chlorophenylethylamine; With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 48h;

With sodium hydroxide; In water; 1,2-dichloro-ethane; for 0.166667h;

DOI:10.1016/j.bmc.2011.04.035

Reference yield: 51.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine (1313885-05-0) → 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-N-methylethanamine (1313884-70-6)

Guidance literature:

formaldehyd; 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine; With formic acid; In water; Reflux;

With sodium hydroxide; In water;

DOI:10.1016/j.bmc.2011.04.035

Reference yield:

2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)ethanamine (1313885-05-0) → 2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-N,N-dimethylethanaminium iodide (1313884-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid / water / Reflux

2: dichloromethane / 20 °C / Inert atmosphere; Darkness

With formic acid; In dichloromethane; water; 1: Eschweiler-Clarke reaction;

DOI:10.1016/j.bmc.2011.04.035

upstream raw materials:

myrtenal

4-chlorophenylethylamine

Downstream raw materials:

2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-N-methylethanamine

2-(4-chlorophenyl)-N-(((1R,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)methyl)-N,N-dimethylethanaminium iodide