N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

Base Information

Chemical Name:N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide
CAS No.:205255-48-7
Molecular Formula:C₂₇H₂₇N₇O₄
Molecular Weight:513.556
Hs Code.:

Synonyms:N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

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Chemical Property of N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

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Technology Process of N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

There total 4 articles about N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 59377-19-4
p-phenoxyphenylisocyanate

: 205259-32-1
7-(ethylamino)-6-nitro-4-(1-piperazinyl)quinazoline

: 205255-48-7
N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

Guidance literature:: DOI:10.1021/jm020505v

Reference yield:

: 53449-14-2
7-chloro-6-nitro-4(3H)-quinazolinone

: 205255-48-7
N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dimethylsulfoxide / 180 °C

2: POCl₃ / Heating

3: propan-2-ol / 4 h / Heating

With trichlorophosphate; In dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1021/jm020505v

Reference yield:

: 168761-50-0
7-(ethylamino)-6-nitroquinazoline-4(3H)-one

: 205255-48-7
N-(4-phenoxyphenyl)-4-(7-ethylamino-6-nitro-4-quinazolinyl)-1-piperazinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: POCl₃ / Heating

2: propan-2-ol / 4 h / Heating

With trichlorophosphate; In isopropyl alcohol;
DOI:10.1021/jm020505v